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Chemical Structure : ZXH-3-26
Catalog No.: PC-35204Not For Human Use, Lab Use Only.
ZXH-3-26 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), shows activity exclusively on the BRD4 BD1 (DC50/5h=5 nM) and spares degradation of BRD2 or BRD3 in cellular degradation assays.
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ZXH-3-26 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), shows activity exclusively on the BRD4 BD1 (DC50/5h=5 nM) and spares degradation of BRD2 or BRD3 in cellular degradation assays; ZXH-3-26 represents the first small molecule to allow pharmacologic targeting of BRD4 without significant inhibition or degradation of BRD2 and BRD3.
| M.Wt | 785.273 | |
| Formula | C38H37ClN8O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nowak RP, et al. Nat Chem Biol. 2018 Jun 11. doi: 10.1038/s41589-018-0055-y.
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