Chemical Structure : ZXH-8-004
CAS No.:
2769858-75-3
ZXH-8-004
(DENV E protein degrader)
Catalog No.: PC-22505Not For Human Use, Lab Use Only.
ZXH-8-004 is a selective and potent PROTAC degrader of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
ZXH-8-004 is cell permeable and able to engage the CRL4CRBN E3 ligase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZXH-8-004 is a selective and potent PROTAC degrader of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
ZXH-8-004 is cell permeable and able to engage the CRL4CRBN E3 ligase.
ZXH-8-004 has excellent selectivity for E with the only other significantly degraded proteins being the well-known 'neosubstrates' derived from the glutarimide recruiter (ZFP91 and GSPT1).
ZXH-8-004 reduces intracellular E starting at a 1.25 μM dose in DENV2-infected Huh7.5 cells.
ZXH-8-004 (2.5, 5 uM) demonstrate markedly increased antiviral efficacy across various serotypes compared to parental inhibitor CVM-2-12-2
Physicochemical Properties
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M.Wt
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861.71
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Formula
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C38H33F6N7O10
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)-3-(trifluoromethoxy)-4-((4-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-2-yl)amino)benzamide
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References
1. Li Z, et al. bioRxiv [Preprint]. 2024 Jun 2:2024.06.01.596987.
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