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ZYZ-488

Chemical Structure : ZYZ-488

CAS No.: 1470302-79-4

ZYZ-488 (ZYZ488)

Catalog No.: PC-62212Not For Human Use, Lab Use Only.

ZYZ-488 is a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1), inhibits the activation of binding protein procaspase-9 and procaspase-3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZYZ-488 is a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1), inhibits the activation of binding protein procaspase-9 and procaspase-3.
ZYZ-488 exhibits cardioprotective effects on hypoxia-induced H9c2 rat ventricular cells.
ZYZ-488 decreases apoptosis in hypoxic H9c2 cells, shows potential for treating cardiac ischemia.

Physicochemical Properties

M.Wt 487.462
Formula C20H29N3O11
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3S,4S,5R,6S)-6-(4-((4-guanidinobutoxy)carbonyl)-2,6-dimethoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

References

1. Wang Y, et al. Sci Rep. 2016 Jul 22;6:29820.

2. Wang Y, et al. Oxid Med Cell Longev. 2017;2017:9747296.

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