Catalog No.: PC-49447Not For Human Use, Lab Use Only.
ZZL-7 (Ac-Ala-Val-OMe) is a small molecule inhibitor of SERT-nNOS interaction, induces a fast-onset antidepressant effect by enhancing serotonin signaling in forebrain circuits.
ZZL-7 (Ac-Ala-Val-OMe) is a small molecule inhibitor of SERT-nNOS interaction, induces a fast-onset antidepressant effect by enhancing serotonin signaling in forebrain circuits.
ZZL-7 disrupts the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN).
ZZL-7 elicited an antidepressant effect 2 hours after treatment without undesirable side effects in vivo.
Physicochemical Properties
M.Wt
244.291
Formula
C11H20N2O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
methyl acetyl-L-alanyl-L-valinate
References
1. Sun N, et al. Science. 2022 Oct 28;378(6618):390-398.
