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Chemical Structure : ZZL-7
Catalog No.: PC-49447Not For Human Use, Lab Use Only.
ZZL-7 (Ac-Ala-Val-OMe) is a small molecule inhibitor of SERT-nNOS interaction, induces a fast-onset antidepressant effect by enhancing serotonin signaling in forebrain circuits.
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ZZL-7 (Ac-Ala-Val-OMe) is a small molecule inhibitor of SERT-nNOS interaction, induces a fast-onset antidepressant effect by enhancing serotonin signaling in forebrain circuits.
ZZL-7 disrupts the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN).
ZZL-7 elicited an antidepressant effect 2 hours after treatment without undesirable side effects in vivo.
| M.Wt | 244.291 | |
| Formula | C11H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sun N, et al. Science. 2022 Oct 28;378(6618):390-398.
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