Zabedosertib (BAY1834845)

Chemical Structure : Zabedosertib

CAS No.: 1931994-81-8

Catalog No.: PC-38683Not For Human Use, Lab Use Only.

Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor with IC50 of 3.4 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway.

Packing	Price	Stock
10 mg	$138	In stock
25 mg	$228	In stock
50 mg	$368	In stock
100 mg	$568	In stock
250 mg		Get quote

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Biological Activity

Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor with IC50 of 3.4 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway.

Physicochemical Properties

M.Wt	470.47
Formula	C20H21F3N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{6-(2-hydroxypropan-2-yl)-2-[2-(methanesulfonyl)ethyl]- 2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2- carboxamide

References

1. Bothe U, et al. J Med Chem. 2024 Jan 25;67(2):1225-1242.

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