Zagociguat | sGC activator | Probechem Biochemicals

Chemical Structure : Zagociguat

CAS No.: 2201048-82-8

Zagociguat (CY-6463, CY6463, IW-6463, IW6463)

Catalog No.: PC-73456Not For Human Use, Lab Use Only.

Zagociguat (CY6463) is a potent, selective, brain-penetrant and orally-active soluble guanylate cyclase (sGC) activator with EC50 of 66 nM in cell-based cGMP asssays.

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5 mg	$228	In stock
10 mg	$368	In stock
25 mg	$598	In stock
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Biological Activity

Zagociguat (CY6463) is a potent, selective, brain-penetrant and orally-active soluble guanylate cyclase (sGC) activator with EC50 of 66 nM in cell-based cGMP asssays.

Zagociguat (CY6463) stimulates the phosphorylation of CREB in a concentration-dependent fashion in rat primary neurons with EC50 of 25.7 nM.

Zagociguat (CY6463) elicits decreases in blood pressure in both rats and mice.

Zagociguat (CY6463) improves cognitive performance in a model of cognitive disruption induced by the administration of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist.

Zagociguat (CY6463) increases long-term potentiation (LTP) in hippocampal slices from a Huntington's disease mouse model and decreases the loss of dendritic spines in aged and Alzheimer's disease mouse models.

Physicochemical Properties

M.Wt	362.292
Formula	C16H10F4N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Imidazo[1,2-a]pyrazine, 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]-

References

1. Correia SS, et al. Front Pharmacol. 2021 May 24;12:656561.

Zagociguat (CY-6463, CY6463, IW-6463, IW6463)

Biological Activity

Physicochemical Properties

References

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