Zaloglanstat | mPGES-1 inhibitor | Probechem Biochemicals

Chemical Structure : Zaloglanstat

Zaloglanstat (ISC-27864, GRC-27864)

Catalog No.: PC-38688Not For Human Use, Lab Use Only.

Zaloglanstat (ISC-27864, GRC-27864) is a potent, selective, non-opioid and orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, exhibits significant analgesic efficacy in preclinical models for osteoarthritis and inflammatory arthritis.

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Biological Activity

Zaloglanstat (ISC-27864, GRC-27864) is a potent, selective, non-opioid and orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, exhibits significant analgesic efficacy in preclinical models for osteoarthritis and inflammatory arthritis.

Physicochemical Properties

M.Wt	452.862
Formula	C21H20ClF3N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-2,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl)pivalamide

References

1. Sant S, et al. Osteoarthritis Cartilage 2018, 26, S351– S352, DOI: 10.1016/j.joca.2018.02.698

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Zaloglanstat (ISC-27864, GRC-27864)

Biological Activity

Physicochemical Properties

References

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