Zalunfiban dihydrochloride | αIIbβ3 integrin antagonist

Chemical Structure : Zalunfiban dihydrochloride

Zalunfiban dihydrochloride (RUC-4 dihydrochloride)

Catalog No.: PC-24715Not For Human Use, Lab Use Only.

Zalunfiban dihydrochloride (RUC-4) is a potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors.

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Biological Activity

Zalunfiban dihydrochloride (RUC-4) is a potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors.

Physicochemical Properties

M.Wt	459.35
Formula	C16H20Cl2N8O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-N-(5-(5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)pyridin-3-yl)acetamide dihydrochloride

References

1. Miller LM, et al. J Med Chem. 2017 Apr 27;60(8):3241-3251.

2. Jiang JK, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53.

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Zalunfiban dihydrochloride (RUC-4 dihydrochloride)

Biological Activity

Physicochemical Properties

References

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