Zanapezil |CAS:263248-42-6 Probechem Biochemicals

Chemical Structure : Zanapezil

Zanapezil (TAK-147;TAK147)

Catalog No.: PC-63361Not For Human Use, Lab Use Only.

Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM.

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Biological Activity

Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM。
Zanapezil (TAK-147) ameliorates the passive avoidance deficit induced by diazepam in animal models at 1-3 mg/kg。
Zanapezil (TAK-147) ameliorates the impairment of DMTP performance induced by scopolamine without affecting the general behavior of the rats.

Physicochemical Properties

M.Wt	492.616
Formula	C29H36N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1- benzazepin-8-yl)-1-propanone fumarate

References

1. Hatip-Al-Khatib I, et al. Br J Pharmacol. 2005 Aug;145(8):1035-44.

2. Hirai K, et al. J Pharmacol Exp Ther. 1997 Mar;280(3):1261-9.

3. Miyamoto M, et al. J Pharmacol Exp Ther. 1996 Jun;277(3):1292-304.

4. Ishihara Y, et al. J Med Chem. 1994 Jul 22;37(15):2292-9.

Zanapezil (TAK-147;TAK147)

Biological Activity

Physicochemical Properties

References

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