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Chemical Structure : Zatebradine
Catalog No.: PC-43527Not For Human Use, Lab Use Only.
Zatebradine (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent.
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Zatebradine (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent.
Zatebradine (UL-FS49) blocks cardiac pacemaker current (If), decreases the rate of spontaneously beating guinea-pig atria with EC50 of 0.030 ug/mL.
| M.Wt | 456.5744 | |
| Formula | C26H36N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Van Bogaert PP, et al. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.
2. McGovern AE, et al. Br J Pharmacol. 2014 Aug;171(15):3633-50.
3. Gill CH, et al. Br J Pharmacol. 2004 Oct;143(3):411-21.
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