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Zaurategrast

Chemical Structure : Zaurategrast

CAS No.: 455264-31-0

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Zaurategrast (CDP-323;CT7758;CDP323)

Catalog No.: PC-45954Not For Human Use, Lab Use Only.

Zaurategrast (CDP-323, CT7758) is a potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist, an ester prodrug of CT-7758.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zaurategrast (CDP-323, CT7758) is a potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist, an ester prodrug of CT-7758.
Zaurategrast (CDP-323, CT7758) is developed for the treatment of multiple sclerosis.

Physicochemical Properties

M.Wt 521.4057
Formula C26H25BrN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

L-Phenylalanine, N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylamino)- (9CI)

References

1. Bailey, et al. Current Immunology Reviews, 2012, 8, 135-140

2. Wolf C, et al. PLoS One. 2013;8(3):e58438.

3. Chanteux H, et al. Drug Metab Dispos. 2014 Jan;42(1):153-61.

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