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Chemical Structure : Zibotentan
CAS No.: 186497-07-4
Catalog No.: PC-42282Not For Human Use, Lab Use Only.
Zibotentan (ZD4054) is an orally active, specific Endothelin A receptor (ETA) inhibitor with Ki of 13 nM, shows anticancer effects.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Zibotentan (ZD4054) is an orally active, specific Endothelin A receptor (ETA) inhibitor with Ki of 13 nM, shows anticancer effects.
Zibotentan (ZD4054) specifically inhibits ETA-mediated antiapoptotic effects, but not ETB-mediated proapoptotic effects in human smooth muscle cells.
Zibotentan (ZD4054) inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo.
| M.Wt | 424.4331 | |
| Formula | C19H16N6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Pyridinesulfonamide, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]- |
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1. Morris CD, et al. Br J Cancer. 2005 Jun 20;92(12):2148-52.
2. Bradbury RH, et al. J Med Chem. 1997 Mar 14;40(6):996-1004.
3. Carducci MA, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6296s-6300s.
4. Rosanò L, et al. Mol Cancer Ther. 2007 Jul;6(7):2003-11.
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