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Chemical Structure : Zilurgisertib
Catalog No.: PC-73458Not For Human Use, Lab Use Only.
Zilurgisertib (INCB000928, NBU-928) is a potent, selective and orally available wild-type and mutant ALK2 (R206H).
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Zilurgisertib (INCB000928, NBU-928) is a potent, selective and orally available wild-type and mutant ALK2 (R206H).
INCB000928 significantly reduces the production of hepcidin in human liver cells, primary hepatocytes and rodent models of anemia.
INCB000928 has shown efficacy in preventing injury-induced heterotopic ossification in a human FOP mouse model, offering a promising path to clinical proof-of-efficacy studies and potential benefits to patients with hepcidin-induced anemia and FOP
| M.Wt | 502.659 | |
| Formula | C30H38N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li J, et al. Preparation of aminopyridine derivatives and their use as selective ALK-2 inhibitors. WO2018014829 A1.
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