Catalog No.: PC-27790Not For Human Use, Lab Use Only.
Zinc pyrithione (Zn-Pyrithione, ZnPy) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump, potentiates potassium currents induced by KCNQ homomultimers, show agonistic activity for KCNQ channels, potently activates both heterologous and native M channels by inducing channel opening at the resting potential, also is a copper ionophore.
Zinc pyrithione (Zn-Pyrithione, ZnPy) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump, potentiates potassium currents induced by KCNQ homomultimers, show agonistic activity for KCNQ channels, potently activates both heterologous and native M channels by inducing channel opening at the resting potential, also is a copper ionophore.
Physicochemical Properties
M.Wt
317.69
Formula
C10H8N2O2S2Zn
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
[O-][N+]1=C(C=CC=C1)S[Zn]SC2=[N+]([O-])C=CC=C2
References
1. Yang-Ming Zhang, et al. J Med Chem. 2021 May 13;64(9):5816-5837.
2. Qiaojie Xiong, et al. Nat Chem Biol. 2007 May;3(5):287-96.
3. Ermolayeva, E. et al. Appl Environ Microbiol, 1995. 61(9): p. 3385-90.
4. Peter Tsvetkov, et al. Science. 2022 Mar 18;375(6586):1254-1261.
