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Ziprasidone hydrochloride

Chemical Structure : Ziprasidone hydrochloride

CAS No.: 122883-93-6

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Ziprasidone hydrochloride (CP-88059 hydrochloride;CP88059 hydrochloride;CP 88059 hydrochloride)

Catalog No.: PC-43964Not For Human Use, Lab Use Only.

A full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively; also is a partial agonist of 5-HT1A, and a partial antagonist of 5-HT2C and 5-HT1D receptors; exhibits potent antipsychotic activity in vivo.

Schizophrenia

Approved

Physicochemical Properties

M.Wt 449.3966
Formula C21H22Cl2N4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-, hydrochloride (1:1)

References

1. Mattei C, et al. J Cent Nerv Syst Dis. 2011 Feb 15;3:1-16.

2. Seeger TF, et al. J Pharmacol Exp Ther. 1995 Oct;275(1):101-13.

3. Schotte A, et al. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73.

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