Ziresovir (RO-0529, AK0529) | RSV F protein inhibitor

Chemical Structure : Ziresovir

CAS No.: 1422500-60-4

Ziresovir (AK-0529, AK0529, RO-0529)

Catalog No.: PC-36105Not For Human Use, Lab Use Only.

Ziresovir (RO-0529, AK0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion protein (RSV F protein) inhibitor, shows anti-RSV activity (EC50=3 nM).

Packing	Price	Stock
5 mg	$288	In stock
10 mg	$458	In stock
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Biological Activity

Ziresovir (RO-0529, AK0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion protein (RSV F protein) inhibitor, shows anti-RSV activity (EC50=3 nM).

Ziresovir shows different efficacy in Wild Type (WT) and Mutant Strains RSV with EC50/EC90 values (μM) of 0.003/0.005 (WT), 2.1/10.0 (D486N), and >10/>10 (D489A), respectively.

Ziresovir inhibits RSV F protein-induced cell–cell fusion process, and suppresses the syncytia formation induced by the RSV F protein.

Ziresovir (12.5 mg/kg, 50 mg/kg, p.o. twice daily, 4 days) results reduction of RSV titer in mouse lung.

Physicochemical Properties

M.Wt	439.534
Formula	C22H25N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(((3-aminooxetan-3-yl)methyl)amino)-6-methylquinazolin-2-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide

References

1. McKimm-Breschkin JL, et al. Antiviral Res. 2018 Jan;149:118-142. doi: 10.1016/j.antiviral.2017.
2. Zheng X, et al. J Med Chem. 2019 Jul 11;62(13):6003-6014.

Ziresovir (AK-0529, AK0529, RO-0529)

Biological Activity

Physicochemical Properties

References

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