Chemical Structure : Zj7923
CAS No.:
2252448-93-2
Zj7923
Catalog No.: PC-24784Not For Human Use, Lab Use Only.
Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1.
Zj7923 could increase the spontaneous firing rate of normal hippocampal pyramidal neurons and ameliorate OGD-induced impairment of neuronal excitability.
Zj7923 provides protection against DTDP-induced apoptosis and its mechanism might be related to the modulation of the expression of apoptosis-related proteins, such as Bcl-2, Bax and cleaved caspase-3 proteins.
Zj7923 significantly reduces infarct volume and improved neurological deficits in rats following transient middle cerebral artery occlusion.
Physicochemical Properties
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M.Wt
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383.49
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Formula
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C22H29N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-ethoxy-5-isobutyramido-N-(1-(3-(methylamino)phenyl)ethyl) benzamide
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References
1. Tianjiao Yang, et al. Neuropharmacology. 2025 May 29:278:110537.
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