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Chemical Structure : Zonampanel
Catalog No.: PC-61711Not For Human Use, Lab Use Only.
Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM.
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Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM.
Zonampanel (YM 872) shows very low affinity for other ionotropic glutamate receptors.
Zonampanel (YM 872) competitively antagonizes kainate-induced currents in Xenopus laevis oocytes with a pA2 value of 6.97.
Zonampanel (YM 872) exhibits great potential for treatment of neurodegenerative disorders such as stroke.
| M.Wt | 331.241 | |
| Formula | C13H9N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shimizu-Sasamata M, et al. Stroke. 1998 Oct;29(10):2141-8.
2. Takahashi M, et al. J Pharmacol Exp Ther. 1998 Feb;284(2):467-73.
3. Kohara A, et al. J Pharm Pharmacol. 1998 Jul;50(7):795-801.
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