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Zongertinib

Chemical Structure : Zongertinib

CAS No.: 2728667-27-2

Zongertinib (BI 1810631, BI-1810631)

Catalog No.: PC-20669Not For Human Use, Lab Use Only.

Zongertinib (BI 1810631, BI-1810631) is a potent, selective HER2 inhibitor, binds to the TKD of HER2 while sparing wild-type EGFR.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zongertinib (BI 1810631, BI-1810631) is a potent, selective HER2 inhibitor, binds to the TKD of HER2 while sparing wild-type EGFR.
Zongertinib (BI 1810631) is a potent and selective inhibitor of HER2-driven oncogenic signaling,  efficiently blocks HER2 mutant-driven lung cancer.
reduces cell growth and survival in mutant HER2 driven Ba/F3 cell systems, in human tumor cell lines in vitro and translated into tumor regressions in a genome-engineered HER2-YVMA mutant xenograft model.

Physicochemical Properties

M.Wt 535.61
Formula C29H29N9O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide

References

1. Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800.
2. John Heymach, et al. Clin Lung Cancer. 2023 Mar;24(2):e65-e68.

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