Chemical Structure : Zosuquidar
CAS No.: 167354-41-8
Catalog No.: PC-23700Not For Human Use, Lab Use Only.
Zosuquidar (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
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Zosuquidar (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
Zosuquidar (LY335979) fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM.
Zosuquidar (LY335979) enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.
M.Wt | 527.62 | |
Formula | C32H31F2N3O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(S)-1-(4-((1aR,6r,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol |
1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.
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