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Zosuquidar

Chemical Structure : Zosuquidar

CAS No.: 167354-41-8

Zosuquidar (LY335979)

Catalog No.: PC-23700Not For Human Use, Lab Use Only.

Zosuquidar (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zosuquidar (LY335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
Zosuquidar (LY335979) fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM.
Zosuquidar (LY335979) enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.

Physicochemical Properties

M.Wt 527.62
Formula C32H31F2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(4-((1aR,6r,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol

References

1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.

2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.

3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.

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