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Zosuquidar trihydrochloride

Chemical Structure : Zosuquidar trihydrochloride

CAS No.: 167465-36-3

Zosuquidar trihydrochloride (LY-335979 trihydrochloride, LY335979)

Catalog No.: PC-45836Not For Human Use, Lab Use Only.

Zosuquidar trihydrochloride (LY-335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Zosuquidar trihydrochloride (LY-335979) is a potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
Zosuquidar trihydrochloride (LY-335979) fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM.
Zosuquidar trihydrochloride (LY-335979) enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.

Physicochemical Properties

M.Wt 636.9871
Formula C32H34Cl3F2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazineethanol, 4-[(1a.alpha.,6.alpha.,10b.alpha.)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-.alpha.-[(5-quinolinyloxy)methyl]-, hydrochloride (1:3), (.alpha.R)-

References

1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.

2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.

3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.

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