Zotemtegrast (LY4268989, MORF-057) | α4β7 integrin inhibitor

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Chemical Structure : Zotemtegrast

Zotemtegrast (LY4268989, LY-4268989, MORF-057, MORF057)

Catalog No.: PC-27517Not For Human Use, Lab Use Only.

Zotemtegrast (LY4268989, MORF-057) is a selecitve, orally bioavailable of alpha4beta7 integrin (α4β7 integrin), inhibits α4β7 integrin-mediated recruitment of α4β7-expressing lymphocytes to the gut.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Zotemtegrast (LY4268989, MORF-057) is a selecitve, orally bioavailable of alpha4beta7 integrin (α4β7 integrin), inhibits α4β7 integrin-mediated recruitment of α4β7-expressing lymphocytes to the gut.

Physicochemical Properties

M.Wt	645.74
Formula	C35H43F4N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[1,1′-Biphenyl]-3-propanoic acid, β-[[(2S)-2-[5-[2-(dimethylamino)ethyl]-2-oxo-4-(trifluoromethyl)-1(2H)-pyridinyl]-4-methyl-1-oxopentyl]amino]-4-fluoro-2′,4′,5,6′-tetramethyl-, (βS)-

References

1. Sands BE, et al. Clin Gastroenterol Hepatol. 2026 Feb;24(2):525-534.

2. Patent WO2021076902 A1 2021-04-22.

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Zotemtegrast (LY4268989, LY-4268989, MORF-057, MORF057)

Biological Activity

Physicochemical Properties

References

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