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cGAMP

Chemical Structure : cGAMP

CAS No.: 849214-04-6

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cGAMP (3',3'-Cyclic GMP-AMP, c-GpAp)

Catalog No.: PC-62663Not For Human Use, Lab Use Only.

cGAMP is a potent STING activator that binds to hSTING R232 and hSTING A230/R232 with Kd of 0.11 uM and 0.16 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

cGAMP (3',3'-Cyclic GMP-AMP, c-GpAp) is a potent STING activator that binds to hSTING R232 and hSTING A230/R232 with Kd of 0.11 uM and 0.16 uM, respectively.
cGAMP activates Type I IFN pathway through the STING/IRF3 pathway.

Physicochemical Properties

M.Wt 674.41
Formula C20H24N10O13P2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Amino-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-3,9-dihydro-6H-purin-6-one

References

1. Gao P, et al. Cell. 2013 Aug 15;154(4):748-62.

2. Zhang X, et al. Mol Cell. 2013 Jul 25;51(2):226-35.

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