Chemical Structure : dASK1-VHL
CAS No.:
3064086-57-0
dASK1-VHL
Catalog No.: PC-24880Not For Human Use, Lab Use Only.
dASK1-VHL is a potent, selective cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
dASK1-VHL is a potent, selective cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1).
dASK1-VHL demonstrates robust ASK1 degradation within the concentration range of 10-100 nM, achieving a maximum reduction of 60% at 50 nM.
dASK1-VHL effectively reduced ASK1 protein levels, suppressed p38 MAPK activation, and decreased hepatic lipid content, indicating significant therapeutic benefits.
Physicochemical Properties
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M.Wt
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986.11
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Formula
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C48H57F2N11O8S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N1-(2,4-Difluoro-5-((6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)carbamoyl)phenyl)-N4-(2-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)ethyl)succinamide
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References
1. Sarkar HS, et al. RSC Med Chem. 2025 Jun 6. doi: 10.1039/d5md00252d.
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