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dBET23

Chemical Structure : dBET23

CAS No.: 1957234-83-1

dBET23

Catalog No.: PC-35214Not For Human Use, Lab Use Only.

dBET23 is a highly effective BRD4 PROTAC degrader, exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    dBET23 is a highly effective BRD4 PROTAC degrader, exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays.

    Physicochemical Properties

    M.Wt 885.39
    Formula C43H45ClN8O9S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl 2-((6S)-4-(4-chlorophenyl)-2-((8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

    References

    1. Nowak RP, et al. Nat Chem Biol. 2018 Jun 11. doi: 10.1038/s41589-018-0055-y.

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