dBET23

Chemical Structure : dBET23

Catalog No.: PC-35214Not For Human Use, Lab Use Only.

dBET23 is a highly effective BRD4 PROTAC degrader, exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays.

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Biological Activity

dBET23 is a highly effective BRD4 PROTAC degrader, exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays.

Physicochemical Properties

M.Wt	885.39
Formula	C43H45ClN8O9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-((6S)-4-(4-chlorophenyl)-2-((8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

References

1. Nowak RP, et al. Nat Chem Biol. 2018 Jun 11. doi: 10.1038/s41589-018-0055-y.

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dBET23

Biological Activity

Physicochemical Properties

References

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