dBET57 |CAS:1883863-52-2 Probechem Biochemicals

Chemical Structure : dBET57

CAS No.: 1883863-52-2

dBET57

Catalog No.: PC-35215Not For Human Use, Lab Use Only.

dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2..

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$158	In stock
25 mg	$278	In stock
50 mg	$478	In stock
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Biological Activity

dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.

Physicochemical Properties

M.Wt	699.183
Formula	C34H31ClN8O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

References

1. Nowak RP, et al. Nat Chem Biol. 2018 Jun 11. doi: 10.1038/s41589-018-0055-y.

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dBET57

Biological Activity

Physicochemical Properties

References

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