Chemical Structure : dBRD9
CAS No.:
2170679-45-3
dBRD9
(dBRD 9)
Catalog No.: PC-60126Not For Human Use, Lab Use Only.
dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Select Batch:
Biological Activity
dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.
dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.
dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.
dBRD9 exhibits antiproliferative effects in human AML cell lines.
Physicochemical Properties
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M.Wt
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783.839
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Formula
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C40H45N7O10
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide
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References
1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.
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