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dCTPP1-IN-1

Chemical Structure : dCTPP1-IN-1

CAS No.: 2098200-95-2

dCTPP1-IN-1

Catalog No.: PC-27240Not For Human Use, Lab Use Only.

dCTPP1-IN-1 is a potent, selective dCTP pyrophosphatase 1 (dCTPase, dCTPP1) inhibitor with IC50 of 36 nM, increases dCTPase thermal and protease stability, displays outstanding selectivity over related enzymes and synergizes with cytidine analogue against leukemic cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

dCTPP1-IN-1 is a potent, selective dCTP pyrophosphatase 1 (dCTPase, dCTPP1) inhibitor with IC50 of 36 nM, increases dCTPase thermal and protease stability, displays outstanding selectivity over related enzymes and synergizes with cytidine analogue against leukemic cells.

Physicochemical Properties

M.Wt 470.52
Formula C22H23FN6O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-fluorobenzyl)-6-(4-((2-methylpyridin-3-yl)sulfonyl)piperazin-1-yl)pyridazine-3-carboxamide

References

1. Hauk G, et al. roc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2534029123.

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