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Chemical Structure : dEALK1
Catalog No.: PC-21776Not For Human Use, Lab Use Only.
dEALK1 is a small-molecule degrader of EML4-ALK fusion proteins with binding constant (Kd) value of 44 nM for kinase domain of recombinant ALK, overcomes resistance to ALK inhibitor ceritinib.
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dEALK1 is a small-molecule degrader of EML4-ALK fusion proteins with binding constant (Kd) value of 44 nM for kinase domain of recombinant ALK, overcomes resistance to ALK inhibitor ceritinib.
dEALK1 is a degrader for WT and multiple ceritinib-resistant EML4-ALK mutants.
dEALK1 (100 nM) selectively degrades EML4-ALK in a CRBN-dependent manner in NSCLC cells H3122 and H2228.
dEALK1 selectively inhibits the proliferation of ALK-rearranged NSCLC cells.
dEALK1 exhibits selective antitumor activity against ALK-rearranged xenograft tumors.
| M.Wt | 1060.66 | |
| Formula | C53H66ClN7O12S: | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xin Li, et al. iScience. 2024 Jan 26;27(2):109015.
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