dEF3122 | NAF-1 inhibitor | Probechem Biochemicals

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Chemical Structure : dEF3122

dEF3122 (dEF 3122)

Catalog No.: PC-21723Not For Human Use, Lab Use Only.

dEF3122 is a highly potent small molecule inhibitor of influenza virus replication with IC50 of 3 nM in neuraminidase activity assays, taregts NEET family of protein NAF-1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

dEF3122 is a highly potent small molecule inhibitor of influenza virus replication with IC50 of 3 nM in neuraminidase activity assays, taregts NEET family of protein NAF-1.
Oral administration of dEF3122 for 8 wk resolved portal inflammation and fibrosis in the liver in mouse model recapitulated phenotypes of NASH associated with chronic kidney disease.
dEF3122 counteracts virus- induced mitochondria network hyperfusion.

Physicochemical Properties

M.Wt	377.46
Formula	C22H19NO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-benzamido-4-(1,2,3,4-tetrahydronaphthalen-2-yl)thiophene-3-carboxylic acid

References

1. Meyniel-Schicklin L, et al. Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2308776121.

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dEF3122 (dEF 3122)

Biological Activity

Physicochemical Properties

References

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