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dHTC1

Chemical Structure : dHTC1

CAS No.: 3081396-69-9

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dHTC1 (rac-dHTC1)

Catalog No.: PC-25533Not For Human Use, Lab Use Only.

dHTC1 (rac-dHTC1) is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 45 nM for ENL, recruits CRL4CRBN to ENL through an extended interface of protein-protein and protein-ligand contacts, but only after pre-forming the ENL:dHTC1 complex.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

dHTC1 (rac-dHTC1) is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 45 nM for ENL, recruits CRL4CRBN to ENL through an extended interface of protein-protein and protein-ligand contacts, but only after pre-forming the ENL:dHTC1 complex.

Physicochemical Properties

M.Wt 676.79
Formula C33H40N8O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-cyclobutyl-2-(3-((2-(4-((6,8-dioxo-2,7-diazaspiro[4.4]nonane)-2-sulfonamido)piperidin-1-yl)ethyl)carbamoyl)phenyl)imidazo[1,2-a]pyridine-6-carboxamide

References

1. Shaum JB, et al. bioRxiv [Preprint]. 2025 Sep 4:2024.09.30.615685.

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