Chemical Structure : dTAGV-1 hydrochloride
CAS No.:
2624313-16-0
dTAGV-1 hydrochloride
(dTAG(V)-1)
Catalog No.: PC-23665Not For Human Use, Lab Use Only.
dTAGV-1 hydrochloride is an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12F36V-tagged proteins.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
dTAGV-1 hydrochloride is an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12F36V-tagged proteins.
Physicochemical Properties
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M.Wt
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1284.01
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Formula
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C68H91ClN6O14S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride
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References
1. Dezhi Li, et al. J Clin Invest. 2024 Dec 24:e174249.
2. Nabet B, et al. Nat Commun. 2020 Sep 18;11(1):4687.
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