Chemical Structure : dTRIM24
CAS No.:
2170695-14-2
dTRIM24
(TRIM24 PROTAC)
Catalog No.: PC-63217Not For Human Use, Lab Use Only.
dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay.
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay.
TRIM24 degradation via dTRIM24 depends on VHL and the proteasome.
dTRIM24 downregulates MYC target genes in AML cell lines, shows antiproliferative effect in acute leukemia.
dTRIM24 is a chemical probe useful for more thorough mechanistic interrogation of TRIM24 in human biology in subsequent research.
Physicochemical Properties
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M.Wt
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1113.312
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Formula
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C55H68N8O13S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-1-((S)-15-(tert-butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1 -benzo[ ]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy- (4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamid
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References
1. Gechijian LN, et al. Nat Chem Biol. 2018 Mar 5. doi: 10.1038/s41589-018-0010-y.
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