dWIZ-1 | WIZ degrader | Probechem Biochemicals

Chemical Structure : dWIZ-1

dWIZ-1 (WIZ degrader)

Catalog No.: PC-22585Not For Human Use, Lab Use Only.

dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.

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Biological Activity

dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-1 increases CRBN-WIZ association with an EC50 of 547 nM.
dWIZ-1 induces HbF expression by direct binding to CRBN and subsequent recruitment and proteasomal degradation of WIZ through WIZ(ZF7).

Physicochemical Properties

M.Wt	399.49
Formula	C22H29N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-((R)-1-((R)-1-ethylpiperidin-2-yl)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. PAMELA Y. TING, et al. SCIENCE, VOL. 385, NO. 670404 JUL 2024 : 91-99

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