dWIZ-1 | WIZ degrader | Probechem Biochemicals

Chemical Structure : dWIZ-1

dWIZ-1 (WIZ degrader)

Catalog No.: PC-22585Not For Human Use, Lab Use Only.

dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-1 increases CRBN-WIZ association with an EC50 of 547 nM.
dWIZ-1 induces HbF expression by direct binding to CRBN and subsequent recruitment and proteasomal degradation of WIZ through WIZ(ZF7).

Physicochemical Properties

M.Wt	399.49
Formula	C22H29N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-((R)-1-((R)-1-ethylpiperidin-2-yl)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. PAMELA Y. TING, et al. SCIENCE, VOL. 385, NO. 670404 JUL 2024 : 91-99

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com