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Chemical Structure : dWIZ-1
Catalog No.: PC-22585Not For Human Use, Lab Use Only.
dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
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dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-1 increases CRBN-WIZ association with an EC50 of 547 nM.
dWIZ-1 induces HbF expression by direct binding to CRBN and subsequent recruitment and proteasomal degradation of WIZ through WIZ(ZF7).
| M.Wt | 399.49 | |
| Formula | C22H29N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. PAMELA Y. TING, et al. SCIENCE, VOL. 385, NO. 670404 JUL 2024 : 91-99
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