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Chemical Structure : eCF506
CAS No.: 1914078-41-3
Catalog No.: PC-61141Not For Human Use, Lab Use Only.
eCF506 (NXP900) is a highly potent, selective, orally available Src family kinase inhibitor with IC50 of <0.5 nM, <0.5 nM and for Src, Yes and Fyn kinases respectively, >950-fold selectivity for Src over ABL.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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eCF506 (NXP900) is a highly potent, selective, orally available Src family kinase inhibitor with IC50 of <0.5 nM, <0.5 nM and for Src, Yes and Fyn kinases respectively, >950-fold selectivity for Src over ABL.
eCF506 displays no significant activity against Kit, mTOR, PDGFRα and RET (IC50>10 uM).
eCF506 suppresses SRC-associated neuromast migration in zebrafish embryos without inducing life-threatening heart defects, and inhibits SRC phosphorylation in tumor xenografts in mice.
| M.Wt | 510.643 | |
| Formula | C26H38N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
tert-Butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)-1-piperidyl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxy-phenyl]carbamate |
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1. Fraser C, et al. J Med Chem. 2016 May 26;59(10):4697-710.
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