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Chemical Structure : eFT508
CAS No.: 1849590-01-7
Catalog No.: PC-42035Not For Human Use, Lab Use Only.
eFT508 (Tomivosertib) is a potent, highly selective, reversible, ATP-competitive, and orally bioavailable MNK1 and MNK2 inhibitor with IC50 of 1-2 nM in enzyme assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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eFT508 (Tomivosertib) is a potent, highly selective, reversible, ATP-competitive, and orally bioavailable MNK1 and MNK2 inhibitor with IC50 of 1-2 nM in enzyme assays.
eFT508 (Tomivosertib) dose-dependently reduces eIF4E phosphorylation at Serine 209 in tumor cell lines with IC50 of 2-16 nM.
eFT508 (Tomivosertib) shows anti-proliferative activity against multiple DLBCL cell lines, decreases the production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10.
eFT508 (Tomivosertib) demonstrates significant anti-tumor activity in human lymphoma xenograft models which harbor activating MyD88 mutations.
| M.Wt | 340.3797 | |
| Formula | C17H20N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
Spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl- |
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1. Kevin R. Webster, et al. Blood 2015 126:1554;
2. Dreas A, et al. Curr Med Chem. 2017;24(28):3025-3053.
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