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eIF2B inhibitor Compound B

Chemical Structure : eIF2B inhibitor Compound B

CAS No.:

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eIF2B inhibitor Compound B

Catalog No.: PC-26715Not For Human Use, Lab Use Only.

eIF2B inhibitor Compound B is a small molecule stabiliser and allosteric inhibitor of inactive state of eIF2B, shows stabilisation effect of the eIF2B:(P)eIF2-NTD interaction, stimulating the Integrated Stress Response (ISR).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

eIF2B inhibitor Compound B is a small molecule stabiliser and allosteric inhibitor of inactive state of eIF2B, shows stabilisation effect of the eIF2B:(P)eIF2-NTD interaction, stimulating the Integrated Stress Response (ISR).

Physicochemical Properties

M.Wt 951.06
Formula C52H60F6N4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-methyl-3-(2-(3-(methyl(6-(3-((N-methylacetamido)methyl)phenyl)-8-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)-3-oxopropoxy)ethoxy)-N-(7-(3-((N-methylacetamido)methyl)phenyl)-5-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)propanamide

References

1. Shilliday F, et al. Nat Commun. 2026 May 6. doi: 10.1038/s41467-026-72688-y.

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