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Chemical Structure : eIF4A3-IN-1q
Catalog No.: PC-60161Not For Human Use, Lab Use Only.
eIF4A3-IN-1q is a potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.
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eIF4A3-IN-1q is a potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM.
eIF4A3-IN-1q displays no activity against eIF4A1, eIF4A2, BRR2 and DHX29 (IC50>100 uM).
eIF4A3-IN-1q upregulates SC35 1.6 kb mRNA expression by 8-fold at 3 uM and 20-fold at 10 uM, potently inhibit cell growth in HCT-116 cells (GI50=1.18 uM).
eIF4A3-IN-1q shows antitumor efficacy and promising PK profiles in vivo, without severe body weight loss.
| M.Wt | 645.861 | |
| Formula | C29H21BrClF3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mizojiri R, et al. ACS Med Chem Lett. 2017 Sep 8;8(10):1077-1082.
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