Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : eIF4A3-IN-2
Catalog No.: PC-62424Not For Human Use, Lab Use Only.
eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases.
eIF4A3-IN-2 suppresses the helicase activity of eIF4A3 in an ATPase-dependent manner.
eIF4A3-IN-2 targets the exon junction complex (EJC) and suppresses monsense-mediated mRNA decay.
| M.Wt | 602.711 | |
| Formula | C25H19Br2ClN4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Iwatani-Yoshihara M, et al. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
