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You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-eIF4A3-IN-2
eIF4A3-IN-2

Chemical Structure : eIF4A3-IN-2

CAS No.: 2095677-20-4

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eIF4A3-IN-2

Catalog No.: PC-62424Not For Human Use, Lab Use Only.

eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    eIF4A3-IN-2 is an allosteric, selective, non-competitive eIF4A3 inhibitor with IC50 of 0.11 uM, exhibits noncompetitive inhibition with ATP or RNA and high selectivity for eIF4A3 over other helicases.
    eIF4A3-IN-2 suppresses the helicase activity of eIF4A3 in an ATPase-dependent manner.
    eIF4A3-IN-2 targets the exon junction complex (EJC) and suppresses monsense-mediated mRNA decay.

    Physicochemical Properties

    M.Wt 602.711
    Formula C25H19Br2ClN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazin-1-yl)(6-bromopyrazolo[1,5-a]pyridin-3-yl)methanone

    References

    1. Iwatani-Yoshihara M, et al. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.

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