Chemical Structure : hIL-1β antagonist Compound (S)-2
CAS No.:
hIL-1β antagonist Compound (S)-2
(Compound (S)-2)
Catalog No.: PC-21192Not For Human Use, Lab Use Only.
Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.
Compound (S)-2 efficiently inhibits reporter activity induced by hIL-1β in a reporter gene assay in HEK293 cells (IC50=5.3 uM), but not hIL-1α.
Compound (S)-2 also shows no inhibitory activity against IL-36γ using a NanoBiT reporter system.
Compound (S)-2 blocks IL-1R-mediated signaling in cells, block IL-6 release with an IC50 in the single digit micromolar rang (IC50=7.9 uM).
Physicochemical Properties
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M.Wt
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469.45
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Formula
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C26H19N3O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid
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References
1. Ulrich Hommel, et al. Nat Commun. 2023 Sep 7;14(1):5497.
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