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Chemical Structure : hIL-1β antagonist Compound (S)-2
Catalog No.: PC-21192Not For Human Use, Lab Use Only.
Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.
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Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM.
Compound (S)-2 efficiently inhibits reporter activity induced by hIL-1β in a reporter gene assay in HEK293 cells (IC50=5.3 uM), but not hIL-1α.
Compound (S)-2 also shows no inhibitory activity against IL-36γ using a NanoBiT reporter system.
Compound (S)-2 blocks IL-1R-mediated signaling in cells, block IL-6 release with an IC50 in the single digit micromolar rang (IC50=7.9 uM).
| M.Wt | 469.45 | |
| Formula | C26H19N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ulrich Hommel, et al. Nat Commun. 2023 Sep 7;14(1):5497.
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