Chemical Structure : iCDM-34
CAS No.:
1005698-44-1
iCDM-34
(iCDM34)
Catalog No.: PC-21584Not For Human Use, Lab Use Only.
iCDM-34 is a small molecule inhibitor with anti-HCV and anti-HBV activities, suppresses HBV DNA and acts as an aryl hydrocarbon receptor (AhR) agonist.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
iCDM-34 is a small molecule inhibitor with anti-HCV and anti-HBV activities, suppresses HBV DNA and acts as an aryl hydrocarbon receptor (AhR) agonist.
iCDM-34 suppresses cellular HBV DNA levels with IC50 of 19.7 uM.
iCDM-34 (30 uM) inhibits medium HBV DNA, HBsAg, and HBeAg with showing a additive effect with entecavir (ETV) in primary cultured human hepatocytes.
iCDM-34 alone does not reduce HBV DNA in the liver, but the combination of iCDM-34 and ETV drastically suppresses the amount of HBV DNA in the liver compared with ETV alone.
iCDM-34 does not induce IFN signaling pathway and induces different characteristic signal pathways compared to CDM-3008 (Cat# PC-21583).
iCDM-34 induces AhR signaling, inhibits phosphorylation of SAMHD1 mediated by CDK1/2, suppresses CDK1/2 mRNA expression.
Physicochemical Properties
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M.Wt
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391.19
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Formula
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C14H11BrN6O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-bromophenyl)-1-((4-nitro-1H-pyrazol-1-yl)methyl)-1H-pyrazole-3-carboxamide
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References
1. Yutaka Furutani, et al. Cell Death Discov. 2023 Dec 22;9(1):467.
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