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Chemical Structure : mPGES-1 inhibitor Compound III
CAS No.: 1268709-57-4
Catalog No.: PC-22479Not For Human Use, Lab Use Only.
mPGES-1 inhibitor Compound III is a selective murine/human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.9/0.09 uM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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mPGES-1 inhibitor Compound III is a selective murine/human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.9/0.09 uM respectively.
Compound III does not inhibit COX-1, COX-2, PGIS or H-PGDS and up to 50 μM.
Compound III (0.1-10 μM) inhibits PGE2 synthesis in cultured A549 cells.
Compound III (20 uM) inhibits PGE2 synthesis in human whole blood and isolated platelets.
Compound III (10-100 mg/kg) inhibits PGE2 synthesis in the mouse air pouch model of inflammation.
| M.Wt | 382.55 | |
| Formula | C23H34N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-Cyclopentyl-1-(1-isopropyl-5,6-dimethyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxamide |
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1. Leclerc P, et al. Prostaglandins Other Lipid Mediat. 2013 Dec;107:26-34.
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