mPGES1-IN-16 |CAS:1915003-93-8 Probechem Biochemicals

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Chemical Structure : mPGES1-IN-16

mPGES1-IN-16

Catalog No.: PC-62820Not For Human Use, Lab Use Only.

mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM.
mPGES1-IN-16 displays no activity against a panel of 35 receptors, ion channels, and hERG.
mPGES1-IN-16 shows IC50/IC80 of 6 nM/24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated human whole blood (HWB); orally bioavailable in vivo.

Physicochemical Properties

M.Wt	485.628
Formula	C30H35N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((1S,2S)-2-(1-(8-methylquinolin-2-yl)piperidine-4-carboxamido)cyclopentyl)ethyl)benzoic acid

References

1. Partridge KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483.

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mPGES1-IN-16

Biological Activity

Physicochemical Properties

References

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