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miR-21-IN-2

Chemical Structure : miR-21-IN-2

CAS No.: 304880-74-8

miR-21-IN-2

Catalog No.: PC-26665Not For Human Use, Lab Use Only.

miR-21-IN-2 is a high-affinity miR-21 inhibitor, binds to the apical loop region of the pre-miR-21 hairpin with KD of 2.3 uM in 2-AP assays, inhibits the maturation of the microRNA hairpin by binding near the apical loop and preventing Dicer processing.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

miR-21-IN-2 is a high-affinity miR-21 inhibitor, binds to the apical loop region of the pre-miR-21 hairpin with KD of 2.3 uM in 2-AP assays, inhibits the maturation of the microRNA hairpin by binding near the apical loop and preventing Dicer processing.

Physicochemical Properties

M.Wt 488.22
Formula C22H20Br2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(o-tolylamino)propan-2-ol

References

1. Connelly CM, et al. Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays. ACS Chem Biol. 2017;12(2):435-443.

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