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Chemical Structure : miR-21 inhibitor 12
Catalog No.: PC-73033Not For Human Use, Lab Use Only.
miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.
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miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.
miR-21-IN-12 inhibited transcription of the miR-21 gene resulting in significant reductions in primary and mature miR-21 levels.
miR-21-IN-12 demonstrated cytotoxicity in a cervical cancer cell line via induction of apoptosis and was capable of reducing microtumor formation in a long-term clonogenic assay.
miR-21-IN-12 shows some level of selectivity for miR-21 and is not a general miRNA pathway inhibitor.
| M.Wt | 408.838 | |
| Formula | C22H17ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ankenbruck N, et al. Bioorg Med Chem. 2019 May 29. pii: S0968-0896(19)30047-1.
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