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miR-21 inhibitor 12

Chemical Structure : miR-21 inhibitor 12

CAS No.: 442522-48-7

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miR-21 inhibitor 12 (miR-21-IN-12)

Catalog No.: PC-73033Not For Human Use, Lab Use Only.

miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.
    miR-21-IN-12 inhibited transcription of the miR-21 gene resulting in significant reductions in primary and mature miR-21 levels.
    miR-21-IN-12 demonstrated cytotoxicity in a cervical cancer cell line via induction of apoptosis and was capable of reducing microtumor formation in a long-term clonogenic assay.
    miR-21-IN-12 shows some level of selectivity for miR-21 and is not a general miRNA pathway inhibitor.

    Physicochemical Properties

    M.Wt 408.838
    Formula C22H17ClN2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(5-Chlorobenzo[d]oxazol-2-yl)phenyl)-2-(4-methoxyphenoxy)acetamide

    References

    1. Ankenbruck N, et al. Bioorg Med Chem. 2019 May 29. pii: S0968-0896(19)30047-1.

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