Chemical Structure : miR-21 inhibitor 37
CAS No.:
miR-21 inhibitor 37
Catalog No.: PC-35404Not For Human Use, Lab Use Only.
miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122; miR-21 inhibitor 37 has no effect on either mature or primary miR-21 levels in HeLa cells, as well as no effect on miR-21 transcription; exhibits low micromolar potency against different established cancer cells (MCF-7 and MIA PaCa-2, IC50=4.5 and 6.7 uM); shows significant rescue of both PDCD4 (9.5-fold increase) and PTEN (1.5-fold increase) levels in A498 RCC cells, sensitizes cells to topotecan-induced apoptosis.
Physicochemical Properties
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M.Wt
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415.413
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Formula
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C21H17N7O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-1-(3-(5-amino-4-(3-(4-(prop-2-yn-1-yloxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one oxime
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References
1. Naro Y, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.7b01891.
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