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mutant IDH1 inhibitor VVS

Chemical Structure : mutant IDH1 inhibitor VVS

CAS No.: 1648909-73-2

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mutant IDH1 inhibitor VVS

Catalog No.: PC-35208Not For Human Use, Lab Use Only.

mutant IDH1 inhibitor VVS is a potent, selective c with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.

    Physicochemical Properties

    M.Wt 366.509
    Formula C22H30N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,6-bis((1H-imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol

    References

    1. Deng G, et al. J Biol Chem. 2015 Jan 9;290(2):762-74.

    2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159.

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