nNOS inhibitor 17

Chemical Structure : nNOS inhibitor 17

Catalog No.: PC-20973Not For Human Use, Lab Use Only.

nNOS inhibitor 17 is a potent, selective neuronal nitric oxide synthase (nNOS) inhibitor with Ki of 15 and 19 nM for rat and human nNOS, respectively.

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Biological Activity

nNOS inhibitor 17 is a potent, selective neuronal nitric oxide synthase (nNOS) inhibitor with Ki of 15 and 19 nM for rat and human nNOS, respectively.
nNOS inhibitor 17 displays 1075-fold selectivity over human eNOS and 115-fold selectivity over human iNOS.
nNOS inhibitor 17 displays excellent cell-membrane permeability along with significantly low P-gp and BCRP substrate liability.

Physicochemical Properties

M.Wt	319.40
Formula	C18H23F2N3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	NC1=NC(CCC2=CC(CCN(C)C)=CC(F)=C2F)=CC(C)=C1

References

1. Vasu D, et al. J Med Chem. 2023 Jul 11. doi: 10.1021/acs.jmedchem.3c00782.

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