Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : p38 MAPK-IN-4
Catalog No.: PC-43250Not For Human Use, Lab Use Only.
p38 MAPK-IN-4 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM for p38α, inhibits LPS-induced TNFα release in THP-1 cells with IC50 of 187 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
p38 MAPK-IN-4 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM for p38α, inhibits LPS-induced TNFα release in THP-1 cells with IC50 of 187 nM.
p38 MAPK-IN-4 displays no signigicant activity against a panel of 54 tyrosine kinases and serine/threonine kinases.
p38 MAPK-IN-4 dose-dependently inhibits TNFα production with an ED50 of 0.5 mg/kg in rat-LPS induced TNFα model, dose-dependently inhibits arthritis progression with ED50 <1 mg/kg, demonstrates a superior efficacy of 4 versus other clinically tested reference compounds like BIRB-796 and VX-745.
| M.Wt | 349.3534 | |
| Formula | C21H15F2N2O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Lumeras W, et al. J Med Chem. 2011 Nov 24;54(22):7899-910.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
