pan-Trk PAM 1 | pan-Trk PAM | Probechem Biochemicals

Chemical Structure : pan-Trk PAM 1

pan-Trk PAM 1 (IGF-1R modulator 1)

Catalog No.: PC-28111Not For Human Use, Lab Use Only.

pan-Trk PAM 1 (IGF-1R modulator 1) is a potent, pan-TRK positive allosteric modulator (PAM) with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB), modulates neurotrophin signalling.

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Biological Activity

pan-Trk PAM 1 (IGF-1R modulator 1) is a potent, pan-TRK positive allosteric modulator (PAM) with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB), modulates neurotrophin signalling.

Physicochemical Properties

M.Wt	387.40
Formula	C22H17N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-(3-methyl-4-phenoxyphenyl)-3-phenyl-

References

1. Patent WO2019162702 A1 ((Example 5).

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pan-Trk PAM 1 (IGF-1R modulator 1)

Biological Activity

Physicochemical Properties

References

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